Exposure to vitamin D from fortified margarine during fetal life and later risk of pre-eclampsia: the D-tect Study

Stougaard M, Damm P

2017

Denmark

Cancellation of the mandatory vitamin D fortification of margarine in 1985 created a societal experiment, with entire adjacent birth cohorts exposed or unexposed to extra vitamin D during fetal development. The Danish national medical health registries allowed the identification of pre-eclampsia cases later in life among all exposed and unexposed female individuals. Women born between June 1983 and August 1988, who gave birth to their first child at age 14·5-27·5 years (n 32 621)were included in the study The risk (95 % CI) for pre-eclampsia among women exposed v. unexposed to extra vitamin D from fortification during fetal development was 0·86 (0·76, 0·97). Exposure to extra vitamin D was associated with further reduced odds of pre-eclampsia (0·49 (0·34, 0·72)) among current smokers, but not among former smokers and non-smokers.

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